Award Data

This proposal seeks to produce a unique thermographic coating inspection system that is customized for the inspection of bridge coatings. This system uses active thermography where IR sources are used to provide controlled heating to a coating system. The presence of a defect in a coating system will result in differences in heat flow, which can be imaged with an infrared camera. An off-the-she ...

Improving the performance of existing superconducting radiofrequency cavities is one approach to improving the capabilities of existing accelerator facilities. By coating existing SRF cavities with Mo3Re, one could realize reduced coat of cryogenics and/or higher accelerating gradients. Alameda Applied Sciences Corp proposes to develop a thin film coating method to produce Mo3Re thin film superco ...

DESCRIPTION (provided by applicant): The Applicant proposes an improvement to monoclonal antibody technology through the generation of transgenic mice engineered to facilitate flow cytometric isolation and cloning of specific antigen-reactive plasmacytes. Monoclonal antibodies (mAbs) are arguably the most important biological reagents used in biomedical research, diagnostics, and therapeutics, and ...

DESCRIPTION (provided by applicant): In this proposal we respond to the call by the National Institute of Environmental Health Sciences (NIEHS) in the PHS 2009-2 Omnibus Solicitation, Exposure Biology Program, Section 1, Technologies for Generating Precise Measures of Environmental Exposures for new products/devices, tools, assays to improve our ability to precisely measure environmental exposure ...

DESCRIPTION (provided by applicant): The objective of this proposal is to develop a less invasive long-term copulsation device to treat patients in late Class III and early Class IV stages of heart failure (HF). Chronic congestive heart failure is the largest unsolved problem in cardiac care today. There are over 5.5 million people in the United States with this diagnosis and the number of patient ...

DESCRIPTION (provided by applicant): The objective of this SBIR program is the modification of a polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement. Key innovations include improved durability and hemodynamic properties, lower manufacturing costs, and simplified delivery over existing transcatheter bioprosthetic v ...

DESCRIPTION (provided by applicant): The overall objective of this proposed program is the commercialization of the Pediatric Impella system, a minimally invasive ventricular assist device (VAD) for treatment of acute heart failure in pediatric patients. The device will be a less traumatic alternative to extracorporeal membrane oxygenation (ECMO), the current standard of care for these patients. T ...

DESCRIPTION (provided by applicant): As the well known baby boomer generation surges toward retirement age, the issue becomes more significant each day of how this generation of 78 million seniors will be able to remain as independent as possible while increasingly burdened by the onset of multiple, chronic, medical conditions and a decline in cognitive abilities. Concurrent with the dramatic incr ...

DESCRIPTION (provided by applicant): This project will develop software for Web-based Compendia , which is defined as a concise, yet comprehensive, organization of a body of knowledge, together with its evaluation. Such Compendia will for a basis for Outlined-Knowledge on the Web. The software will use a new standard, the Web-Citation-Protocol. The Protocol offers a new method of creating refer ...

DESCRIPTION (provided by applicant): Methadone is an important long-term maintenance therapy for drug addiction and currently is frequently used for analgesia. However, methadone prolongs the QT interval on the electrocardiogram and this increases risk for life threatening arrhythmias and has led to the FDA's placing a black box warning on methadone's label. Initial studies in our laboratory hav ...