Award Data

PI: Savoy Project Summary Tissue protection following injury begins with shutting down vasodilation and limiting subsequent swelling through the application of cold. In many cases, the cold comes in the form of bags of ice or frozen cold packs, or commercial cooling products such ice packs or ice pack holding limb wraps. In others it may be via a chilled water circulator device, for example the Po ...

ABSTRACT Pulmonary arterial hypertension (PAH) is a fatal disease (without curative therapies) that is critically influenced by dysregulated inflammatory pathways. This A1 R42 Fast Track STTR application focuses on eNAMPT (extra- cellular nicotinamide phosphoribosyltransferase) as a novel, highly attractive PAH target. Aqualung Therapeutics has developed a humanized eNAMPT-neutralizing mAb, ALT-10 ...

AbstractTreatment of non-resectable recurrent/metastatic solid cancers is currently palliative only and there is an urgent unmet need for novel mechanisms of action and additional paradigm shifting therapeutic options. Antigen- targeting cancer immunotherapies such as bi-specific antibodies (eg Bi-specific T cell engager or BiTE’s) provide a unique approach for cancer immunotherapy. However, app ...

PROJECT SUMMARY/ABSTRACTAfrican American men have the highest rate of hypertension (HTN) in the United States. Once diagnosed, they are also less likely to achieve blood pressure (BP) control. This health disparity is critical, as elevated BP is the primary modifiable risk factor for cardiovascular disease. One reason for this HTN disparity: stress. African Americans report more stress than their ...

PROJECT SUMMARY Patients with limited English proficiency (LEP) continue to experience a range of health disparities compared to English-proficient patients. Addressing persistent gaps in language services requires a paradigm shift in which health systems evaluate and track their compliance with relevant regulations, implement staff training, and carefully craft and communicate exhaustive language ...

The objective of this VAS rangefinder Phase I SBIR effort is to complete key enabling trade studies which will inform the development of the range finder through a Phase II effort. The resulting VAS rangefinder will be a low-cost, easy-to-use device that is capable of operating 24/7 in urban or near-urban environments with ambient light sources.

IERUS is developing a novel phased array ground terminal aperture architecture for the DoD's next generation of satellite constellations. With the proliferation of high-bandwidth satellites across LEO, MEO, and GEO, there is a need for SWaP-C optimized user terminal apertures. The IERUS solution implements scalable and mission-set reconfigurable technologies to enable rapid transition into operati ...

Augmentation Systems (VAS) Range Finder. It provides opportunities for day/night observation and range measurement in a small, easy-to-use device. We tradeoff features and SWAP-C to determine optimal combinations and document them in a feasibility study. Novel methods of presenting ranges are further. investigated and discussed.

Attollo Engineering proposes to address the need for a quick-draw, pouch-storable laser rangefinder for day and night urban use. This self-contained unit will weigh less than 18 ounces and have a total volume less than 64 cubic inches. The system will provide post-fire target assurance, showing the operator where the laser landed on the target. In Phase I Attollo will survey and evaluate all relev ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project relates to the creation of a digital twin, an interactive, 3-dimensional model of a real-world system, of complex industrial environments and assets. This digital twin provides infrastructure necessary for the application of virtual reality training and augmented reality live-guided procedure ...