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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 207711 - 207720 of 207731 results
  1. Innate Immune Protection by Clean Genome E. coli

    SBC: SCARAB GENOMICS LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Complications arising from pathogen infection incur a tremendous societal cost both in morbidity and mortality (as high as 50-60%), as well as in care and treatment estimated in billions of dollars. In susceptible patients, infection induces mis-regulation of the innate immune system that can culminate in systemic inflammation, severe illness and death. The dev ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Toxoid adjuvant CRM197 production in a stable reduced genome E. coli strain

    SBC: SCARAB GENOMICS LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): Scarab Genomics has developed valuable reduced-genome strains of Escherichia coli in which multiple deletions remove from the genome much unwanted and all potentially hazardous DNA. These Clean Genome(R) strains, alongwith Scarab's gene expression technology, provide a system for producing high yields of premium-quality proteins very efficiently. In this P ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  3. A protease-deficient, low mutation rate E. coli for biotherapeutics production

    SBC: SCARAB GENOMICS LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics manufacture, continues to be the most economical method of generating proteins that do not require ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Characterization of a low mutation rate E. coli in extended fermentation

    SBC: SCARAB GENOMICS LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This application aims to test a new Scarab E. coli strain, MDS42pdu, for commercial fermentation to produce biopharmaceuticals, amino acids and biofuels. It is designed for a very low rate of point mutations and Insertion Sequence transposition, especially in the stress conditions of recombinant protein production. We propose here to study the impact on a funda ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. A protease-deficient, low mutation rate E. coli for biotherapeutics production

    SBC: SCARAB GENOMICS LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Biotherapeutics is a fast-growth sector in the pharmaceutical market with monoclonal antibodies accounting for almost 50% of the 100 billion USD spent each year on protein therapies. Bacterial fermentation, which accounts for about 35% of all protein therapeutics manufacture, continues to be the most economical method of generating proteins that do not require ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  6. An Automated Sample Handling Workcell for the SNS Liquids Reflectometer

    SBC: SQUARE ONE SYSTEMS DESIGN, INC.            Topic: 23a

    78887 When completed, the Spallation Neutron Source (SNS) will provide unprecedented opportunities for performing groundbreaking neutron science. Two reflectometers are planned for the SNS, one optimized for the measurement of liquid surfaces and the other for the measurement of magnetic materials. The SNS¿s high neutron flux will allow these instruments to collect complete data sets in minu ...

    STTR Phase I 2005 Department of Energy
  7. An Automated Sample Handling Workcell for the SNS Liquids Reflectometer

    SBC: SQUARE ONE SYSTEMS DESIGN, INC.            Topic: 23

    When completed, the Spallation Neutron Source (SNS) will provide unprecedented opportunities for performing groundbreaking neutron science. Two reflectometers are planned for the SNS, one optimized for the measurement of liquid surfaces and the other for the measurement of magnetic materials. The SNS¿s high neutron flux will allow these instruments to collect complete data sets in minutes rat ...

    STTR Phase II 2006 Department of Energy
  8. A Compact Crystal Positioning System for Neutron Diffraction

    SBC: SQUARE ONE SYSTEMS DESIGN, INC.            Topic: 23

    79518S When completed, the Spallation Neutron Source¿s (SNS) multiple beamlines will provide unprecedented opportunities to conduct studies in materials characterization, medical isotope production, and the transmutation of nuclear waste. However, the large goniometers traditionally used to position samples relative to particle beams will be incompatible with many of the new SNS instruments. ...

    SBIR Phase I 2005 Department of Energy
  9. A Compact Crystal Positioning System for Neutron Diffraction

    SBC: SQUARE ONE SYSTEMS DESIGN, INC.            Topic: 23

    When completed, the Spallation Neutron Source¿s (SNS) multiple beam lines will provide unprecedented opportunities to conduct studies in materials characterization, medical isotope production, and the transmutation of nuclear waste. However, to take full advantage of the greatly reduced data collection times made possible by the SNS¿s high neutron flux, new automated sample changers must be ...

    SBIR Phase II 2006 Department of Energy
  10. An Automated Magnet Positioning System for Use in the Next Linear Collider

    SBC: SQUARE ONE SYSTEMS DESIGN, INC.            Topic: 7

    76147-The Next Linear Collider (NLC) will use a beam-based alignment strategy to measure and then correct errors in the positions of the lattice elements. To implement this strategy, ultra-high-resolution beam position monitors and automated component adjustment systems have been identified as critical enabling technologies. This project will develop a fully-automated precision manipulator, the ...

    SBIR Phase I 2004 Department of Energy
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