Award Data

To address the Air Force need for a new technique for automation of aircraft skin attachment and assembly and Outer Mold Line (OML) control, Physical Optics Corporation (POC) proposed and successfully demonstrated in Phase I a new metrology system for precise thickness measurements of composite panels and fast measurements of steps and gaps between the panels in the aircraft assembly, utilizing a ...

The proposed scope of work is intended to comprise efforts to implement a production capable Electron Beam Direct Manufacturing (EBDM)system intended to produce parts with sufficient quality and affordability to meet Air Force program requirements. The scope deals not only with the EBDM process specifically but the entire supply chain which is involved with delivering finished titanium aerospace s ...

By a direct extension of our Phase II contract with NASA, we propose to realize a prototype of a neuromorphic chip able to withstand heavy dosage of radiations, like those encountered in the Lunar environment. The neuromorphic chip will have multiple use in a space system, from sensor data analysis to control or to system diagnosis.In particular, during our concluded Phase II we realized a test ch ...

ProtoInnovations, LLC proposes to continue the advancement and maturation of the Rover-Based Non-Prehensile Manipulation for Improved Mobility, Scientific Exploration and Terrain Shaping on Planetary Surfaces (RBNPM, NASA Phase II SBIR Contract #80NSSC19C0215) software control architecture and algorithms to enable robotic rovers to perform autonomous or semi-autonomous excavating, transporting, an ...

Hydrothermal vents emit large amounts of hot water, which has the potential to produce electric power. This type of power source can enable remote sea sensors and communication networks, recharge unmanned underwater vehicles, and facilitate a variety of other deep sea activities. Developing a power system for this application is challenging because the environment is extremely corrosive, mineral p ...

DESCRIPTION (provided by applicant): The goal of this Type 2 Competitive Renewal SBIR application to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct a phase I/II clinical trial to investigate the safety and earlyefficacy of a novel antimicrobial living human skin substitute for the treatment of a life-threatening complication of diabetes: chronic, nonhea ...

Project Summary Cytoprotective and restorative treatments for acute ischemic stroke (AIS) is a major unmet medical need. The current standard of care for stroke patients is centered on recanalization efforts to restore cerebral perfusion through the administration of tissue plasminogen activator (tPA) or mechanical thrombectomy. However, despite a recent extension of recanalization treatment windo ...

DESCRIPTIONprovided by applicantHuntington s DiseaseHDis an inherited disease that results from expansion of a trinucleotideCAGcytosine adenine guaninerepeat that encodes a polyglutamine tract in the huntingtin proteinPsychiatric symptomsincluding irritability and aggressionare common in HD patientsThese are among the most distressing aspects of the diseaseThey have adverse effects on daily life a ...

Project Summary/Abstract: As stated in the Notice of Special Interest announcement, there is a need to populate the recently established MPS database with existing data generated by organ-on-a-chip systems. Having a centralized, public database with data from all available MPS systems will accelerate development and acceptance of the technology ultimately bringing better therapies to patients fast ...

Bladder cancer is the 5th most prevalent cancer with over 700,000 people living with the disease in the US. The disease has a particularly high patient burden as it recurs in 70% of patients following initial treatment. Over half of these patients do not respond or progress while on treatment or surveillance. New therapeutic and diagnostic options are needed for patients undergoing diagnosis and r ...