| Year | Individual/ Company | Name | State | Web URL |
| 2000 | I | Carl G. Ray | DC | |
| 2000 | I | Dana Grow | ND | |
| 2000 | I | Daniel O. Hill | DC | |
| 2000 | I | David M. Nelms | AR | |
| 2000 | I | Diana Endicott | KS | |
| 2000 | I | Donald R. Snyder | FL | |
| 2000 | I | Donald W. Upson | VA | |
| 2000 | I | James P. Murphy | WY | |
| 2000 | I | Joe Graben | MS | |
| 2000 | I | Jonathon Baron | VA | |
| 2000 | I | Kenneth L. Jones | NC | |
| 2000 | I | Mark K. Herring | AL | |
| 2000 | I | Philip Z. Sobocinski | WI | |
| 2000 | I | Ram Murty | KY | |
| 2000 | I | Robert E. Berger | MD | |
| 2000 | I | Scott Blake | MA | |
| 2000 | I | Terry Brewer | MO | |
| 2000 | I | Zybron, Inc. | OH | |
| 2000 | C | Adherence Technologies Corp. | VA | https://www.sbir.gov/sbirsearch/detail/71911 |
| 2000 | C | Advanced Acoustic Concepts | NY | https://www.sbir.gov/sbirsearch/detail/73091 |
| 2000 | C | Advanced Fuel Research, Inc. | CT | https://www.sbir.gov/sbirsearch/detail/74814 |
| 2000 | C | AeroAstro, Inc. | VA | https://www.sbir.gov/sbirsearch/detail/79287 |
| 2000 | C | Architecture Technology Corporation | MN | https://www.sbir.gov/sbirsearch/detail/96167 |
| 2000 | C | ARNAV Systems, Inc. | WA | https://www.sbir.gov/sbirsearch/detail/97516 |
| 2000 | C | Boeing-svs, Inc. | NM | |
| 2000 | C | Camas International, Inc. | ID | https://www.sbir.gov/sbirsearch/detail/116299 |
| 2000 | C | Compact Membrane Systems | DE | https://www.sbir.gov/sbirsearch/detail/130036 |
| 2000 | C | Creative Optics, Inc. | NH | https://www.sbir.gov/sbirsearch/detail/137726 |
| 2000 | C | Cryomagnetics, Inc. | TN | https://www.sbir.gov/sbirsearch/detail/138361 |
| 2000 | C | Danya International | MD | https://www.sbir.gov/sbirsearch/detail/141881 |
| 2000 | C | DEKK-TEC, Inc. | LA | https://www.sbir.gov/sbirsearch/detail/144229 |
| 2000 | C | Dharmacon Research, Inc. | CO | https://www.sbir.gov/sbirsearch/detail/145479 |
| 2000 | C | Diamond Visionics LLC | NY | https://www.sbir.gov/sbirsearch/detail/145775 |
| 2000 | C | Frank L. Roddey SBDC | SC | |
| 2000 | C | FuelCell Energy, Inc. | CT | https://www.sbir.gov/sbirsearch/detail/157877 |
| 2000 | C | Harris FRC Corporation | NJ | https://www.sbir.gov/sbirsearch/detail/179438 |
| 2000 | C | Hawaii Fish Company | HI | https://www.sbir.gov/sbirsearch/detail/690145 |
| 2000 | C | Hearing Components, Inc. | MN | https://www.sbir.gov/sbirsearch/detail/1046571 |
| 2000 | C | Hobi Labs, Inc. | CA | https://www.sbir.gov/sbirsearch/detail/182218 |
| 2000 | C | Hood Technology Corporation | OR | https://www.sbir.gov/sbirsearch/detail/182627 |
| 2000 | C | Imlach Consulting Engineering | AK | https://www.sbir.gov/sbirsearch/detail/188088 |
| 2000 | C | Intelligent Automation, Inc. | MD | https://www.sbir.gov/sbirsearch/detail/198064 |
| 2000 | C | Ixion Biotechnology, Inc. | FL | https://www.sbir.gov/sbirsearch/detail/204849 |
| 2000 | C | Ligocyte Pharmaceuticals, Inc. | MT | https://www.sbir.gov/sbirsearch/detail/216533 |
| 2000 | C | Metal Tech Industries, Inc. | IA | |
| 2000 | C | Metrica, Inc. | TX | https://www.sbir.gov/sbirsearch/detail/231471 |
| 2000 | C | Noesis, Inc. | VA | https://www.sbir.gov/sbirsearch/detail/250203 |
| 2000 | C | Nova Engineering, Inc. | OH | https://www.sbir.gov/sbirsearch/detail/251616 |
| 2000 | C | Opticomp Corporation | NV | https://www.sbir.gov/sbirsearch/detail/257332 |
| 2000 | C | Optobionics Corporation | IL | https://www.sbir.gov/sbirsearch/detail/258193 |
| 2000 | C | RDA, Inc. | PA | https://www.sbir.gov/sbirsearch/detail/288870 |
| 2000 | C | Scientific Research Corporation | GA | |
| 2000 | C | Sensor Research and Development Corporation | ME | https://www.sbir.gov/sbirsearch/detail/700345 |
| 2000 | C | Systems Engineering Associates Corporation | RI | https://www.sbir.gov/sbirsearch/detail/302173 |
| 2000 | C | T.J. Enterprises | SD | https://www.sbir.gov/sbirsearch/detail/325106 |
| 2000 | C | Tacan Corporation (IPITEK) | CA | https://www.sbir.gov/sbirsearch/detail/203127 |
| 2000 | C | TeraComm Research, Inc. | VT | https://www.sbir.gov/sbirsearch/detail/932193 |
| 2000 | C | The Stover Group | OK | https://www.sbir.gov/sbirsearch/detail/318976 |
| 2000 | C | Thermoanalytics, Inc. | MI | https://www.sbir.gov/sbirsearch/detail/333376 |
| 2000 | C | Transonic Systems, Inc. | NY | https://www.sbir.gov/sbirsearch/detail/337319 |
| 2000 | C | Triangle Research and Development Corporation | NC | https://www.sbir.gov/sbirsearch/detail/901271 |
| 2000 | C | Visual Computing Systems Corporation | IN | https://www.sbir.gov/sbirsearch/detail/347672 |
| 2000 | C | Zona Technology, Inc | AZ | https://www.sbir.gov/sbirsearch/detail/354639 |
